منابع مشابه
A Primer on Vesicle Budding
How do vesicular coats form on the donor membrane? Sebastian Springer,* Anne Spang,* and Randy Schekman*†‡ Do cargo proteins influence this process? Recent work *Department of Molecular and Cell Biology and on the exchange of proteins between the endoplasmic †Howard Hughes Medical Institute reticulum (ER) and the Golgi apparatus in SaccharoUniversity of California myces cerevisiae and higher eu...
متن کاملBudding and fission of a multiphase vesicle.
We present a model of bi-phasic vesicles in the limit of large surface tension. In this regime, the vesicle is completely stretched and well described by two spherical caps with a fold, which concentrates the membrane stress. The conservation laws and geometric constraints restrict the space of possible shapes to a pair of solutions labeled by a parameter sigma given by line tension/pressure. F...
متن کاملBudding yeast for budding geneticists: a primer on the Saccharomyces cerevisiae model system.
The budding yeast Saccharomyces cerevisiae is a powerful model organism for studying fundamental aspects of eukaryotic cell biology. This Primer article presents a brief historical perspective on the emergence of this organism as a premier experimental system over the course of the past century. An overview of the central features of the S. cerevisiae genome, including the nature of its genetic...
متن کاملThe Mechanisms of Vesicle Budding and Fusion
Genetic and biochemical analyses of the secretory pathway have produced a detailed picture of the molecular mechanisms involved in selective cargo transport between organelles. This transport occurs by means of vesicular intermediates that bud from a donor compartment and fuse with an acceptor compartment. Vesicle budding and cargo selection are mediated by protein coats, while vesicle targetin...
متن کاملPoliovirus infection transiently increases COPII vesicle budding.
Poliovirus (PV) requires membranes of the host cell's secretory pathway to generate replication complexes (RCs) for viral RNA synthesis. Recent work identified the intermediate compartment and the Golgi apparatus as the precursors of the replication "organelles" of PV (N. Y. Hsu et al., Cell 141:799-811, 2010). In this study, we examined the effect of PV on COPII vesicles, the secretory cargo c...
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ژورنال
عنوان ژورنال: Cell
سال: 1999
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80722-9